6.—(1) Every licensee shall ensure that the handling, care and treatment of any animal used for any scientific purpose in his or its research facility, including the transportation of such animal to and from the research facility, conforms to —
(a)
the provisions of these Rules;
(b)
the conditions of his or its licence issued under rule 4; and
(c)
the relevant guidelines issued or adopted, and the relevant directives issued, by the Director-General under rule 18.
(2) Every licensee shall, within such time and in such manner as the Director-General may require, inform the Director-General of any change to the operations or personnel of his or its research facility.